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September 9, 2023MicroorganismsOpen Access

A Fatal A/H5N1 Avian Influenza Virus Infection in a Cat in Poland

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Authors

OSOlga Szaluś‐JordanowAGAnna GolkeTDTomasz Dzieciątkowski

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Overview

Case report reveals fatal systemic A/H5N1 avian influenza infection with severe neurological and respiratory pathology in a domestic cat, highlighting cross-species transmission risks.

Key Points

  • To describe the clinical progression, pathological lesions, and diagnostic confirmation of a fatal A/H5N1 avian influenza infection in a domestic cat.
  • Examined a 6-year-old male neutered European Shorthair cat presenting with apathy, anorexia, respiratory distress, and epileptic seizures using thoracic ultrasound.
  • Performed post-mortem histopathological evaluations of internal organs and brain tissue.
  • Identified viral RNA across multiple organ tissues using one-step real-time reverse transcription polymerase chain reaction (RT-qPCR) and conducted microbial culture.
  • Lung ultrasound demonstrated consolidations and numerous B lines, followed by progression to cardiac and respiratory arrest within six days of presentation.
  • Post-mortem examination identified necrotic lesions in the liver, lungs, and intestines, alongside cerebral perivascular infiltration of lymphocytes and histiocytes with focal neuronal necrosis.
  • RT-qPCR confirmed generalized A/H5N1 virus infection throughout multiple tissues, alongside pure culture isolation of multidrug-resistant Enterococcus faecium from internal organs.

Cite This Study

Szaluś‐Jordanow et al. (2023) studied this question.

synapsesocial.com/papers/6a7056698031ec7bb1dc457chttps://doi.org/10.3390/microorganisms11092263
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Course, Laboratory Findings, and Tissue Distribution of Highly Pathogenic Avian Influenza A(H5N1) Virus in a Naturally Infected Domestic Cat2026
  2. 2Clinical and Laboratory Findings in Cats with Confirmed Avian Influenza A/H5N1 Virus Infection During the 2023 Outbreak in Poland: A Retrospective Case Series of 22 Cats2026 · 2 citations
  3. 3Multisystemic manifestations of highly pathogenic avian influenza (H5N1) in a young domestic shorthair cat2025
  4. 4Highly pathogenic avian influenza A H5N1 virus infection in an immunocompromised domestic cat2025
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