This review explores nano-calcium carbonate applications in biomedicine and environmental sectors, highlighting synthesis challenges.
Research on nano‐calcium carbonate, a nano‐scale branch of calcium carbonate, has gained prominence because of its large specific surface area, low biological toxicity, and superior biocompatibility, driving its extensive application in industrial processes and daily life. Recent advancements in synthesis techniques have improved the production efficiency and functional performance. However, developing scalable methods for producing high‐purity nano‐calcium carbonate that optimize both economic feasibility and environmental sustainability remains a critical challenge. Further investigation is required to advance intelligent and multifunctional high‐performance composite applications. To provide a comprehensive understanding of the current state of nano‐calcium carbonate research and expedite the translation of associated preparation and application technologies, this review begins with a multimethod preparation of nano‐calcium carbonate, focusing on its application in daily necessities, biomedicine, and the environment. It also explores how nano‐calcium carbonate enhances material performance and evaluates its impact before and after incorporation. In addition, the integration of artificial intelligence into nanoparticle research has been discussed as a promising strategy for optimizing synthesis, improving property prediction, and accelerating innovation. These insights aim to provide a comprehensive understanding of nano‐calcium carbonate while identifying future research directions to drive advancements in its applications.
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Cai et al. (2025) studied this question.
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