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September 30, 2025Open Access

Investigating the association between maternal infection and inflammation and child autistic traits in a large population based cohort study

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Authors

FGFrederieke GigaseMZMilan ZarchevRMRyan L. Muetzel

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Overview

Cohort study found no significant link between prenatal inflammation and autistic traits in children, suggesting limited influence.

Key Points

  • No significant associations were found between maternal inflammatory exposures and child autistic traits, both continuous and clinical measures.
  • Despite examining 5,075 mother-child dyads, prenatal inflammatory exposures didn’t correlate with autistic traits in children under study.
  • Interaction terms indicated no moderating effect of child polygenic score on the relationship between inflammatory exposures and autistic traits.
  • These findings suggest typical variations in maternal inflammation do not majorly influence autism risk, highlighting complexity of its origins.

Cite This Study

Gigase et al. (2025) studied this question.

synapsesocial.com/papers/68dc1e3b8a7d58c25ebb1bb9https://doi.org/10.1101/2025.09.11.25335326
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prenatal exposure to common infections and newborn DNA methylation: A prospective, population-based study2024 · 1 citations
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  4. 4Prenatal and birth factors associated with child autism diagnosis: a birth cohort perspective2026 · 1 citations
  5. 5Parental psychiatric diagnoses as predictive factors for autism spectrum disorder in the child: confluence of genetics and environment2024 · 1 citations