Meta-analysis reveals significant link between elevated triglyceride levels and aspirin resistance in stroke patients, suggesting a need for further study.
Objectives: Resistance to acetylsalicylic acid (ASA) (aspirin) in ischaemic stroke (IS) patients may correspond with an altered lipid profile. The present study was commenced to explore the association of blood lipid profiles and ASA (Aspirin) resistance in IS patients. Materials and Methods: Research published on or before September 2024 in Medline, PubMed, EMBASE and Google Scholar was chosen for this study. Random effects models were applied to evaluate the pooled standardised mean and standard deviation with a 95% confidence interval (CI). RevMan 5 and STATA version 13.0 software were used for statistical analysis. Results: This meta-analysis included data from eight studies involving both aspirin-resistant and aspirin-sensitive subjects. Our results indicated a significant association between elevated triglyceride levels and aspirin resistance compared to non-resistance (standard mean difference= 0.83, 95% CI : 0.30–1.95, P < 0.001). However, the meta-influence analysis showed no significant association when a study with a large effect size was excluded. Conclusion: The comprehensive meta-analysis found no significant association between lipid parameters and aspirin resistance. Additional studies may be necessary to further validate these findings.
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Vardhan et al. (2025) studied this question.
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