Key result
Aspirin resistance shows no significant link to elevated triglycerides after excluding one large-effect study.
Why the study?
Aspirin resistance has been linked to altered blood lipid profiles in ischemic stroke patients, but the association remains unclear.
Is aspirin resistance associated with altered blood lipid profiles in patients with ischemic stroke?
Meta-Analysis
Is aspirin resistance associated with altered blood lipid profiles in patients with ischemic stroke?
Standardized Mean Difference: 0.83 (95% CI 0.3–1.95)
p-value: p=< 0.001
This meta-analysis found no robust significant association between lipid parameters and aspirin resistance in ischemic stroke patients.
No robust lipid-aspirin resistance link in ischemic stroke; leaves open need for prospective confirmation before clinical consideration.
In ischemic stroke patients, aspirin resistance has been linked to an altered lipid profile. This study was undertaken to explore the association of blood lipid profiles with aspirin resistance in ischemic stroke patients. Relevant studies published before November 2022 in PubMed, Medline, EMBASE, and Google Scholar were chosen for this study. Random effects models were used to assess pooled standardized mean and standard deviation (SD) with a 95% confidence interval (CI). RevMan 5 and STATA version 13.0 software were used for statistical analysis. Subjects from eight studies consisting of aspirin resistance and sensitive data were considered in this meta-analysis. Our findings suggested a significant association between the elevated levels of TG in Aspirin resistance groups as compared to non-resistance (SMD 0.83, 95% CI 0.30 to 1.95, p-value < 0.001). However, the meta-influence analysis suggested no significant association when a study with a large effect size was excluded. The results of our comprehensive meta-analysis suggest none of the lipid parameters were significantly associated with aspirin resistance. Further studies might be required to support the findings of this meta-analysis.
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Vardhan et al. (2023) conducted a meta-analysis in Ischemic stroke. Aspirin resistance vs. Aspirin non-resistance was evaluated on Elevated levels of triglycerides (TG) (SMD 0.83, 95% CI 0.30 to 1.95, p=< 0.001). Aspirin resistance was initially associated with elevated triglycerides (SMD 0.83; 95% CI 0.30-1.95; p<0.001), but this association became non-significant after excluding a large-effect study.
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