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September 30, 2025Discover OncologyOpen Access

Multiomic Mendelian randomization analysis of metabolic gene methylation expression and protein levels in lung adenocarcinoma

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Authors

QWQing WangGLGang LiuJZJun Zhang

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Overview

This study explores the association between metabolic gene features and lung adenocarcinoma risk using Mendelian randomization, highlighting critical molecular targets for potential treatment.

Key Points

  • Significant associations between specific metabolic genes and lung adenocarcinoma risk were identified.
  • Methylation changes in CHRNA3 were linked to increased lung adenocarcinoma risk, with validation from the FinnGen cohort.
  • Mendelian randomization revealed robust connections between gene expression and lung adenocarcinoma, supporting potential therapeutic targets.
  • Protective effects of specific protein levels like POGLUT3 were noted, emphasizing the complexity of metabolic dysregulation in cancer.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68dc261d8a7d58c25ebb2920https://doi.org/10.1007/s12672-025-03600-1
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