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October 1, 2025International Journal of Science and Healthcare ResearchOpen Access

Hematology Parameters and Clinical associations in Children with Steady-State Sickle Cell Anemia in Southwest Nigeria

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Authors

SOSamuel Olorunyomi OninlaOOOyetoke Christina OderantiMAMoshood Adebayo Akintola

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Overview

Cross-sectional study identifies hematology parameters in children with sickle cell anemia, suggesting hydroxyurea relates to transfusion frequency.

Key Points

  • A high mean white blood cell count was significantly associated with disease severity in children.
  • The study involved 110 children with steady-state sickle cell anemia, revealing gender and age differences in hematology parameters.
  • Samples were analyzed using a hematology auto analyzer and enzyme-linked immunosorbent assay for fetal hemoglobin assessment.
  • The findings underscore the potential role of hydroxyurea in managing sickle cell anemia, with calls for multicenter studies.

Cite This Study

Oninla et al. (2025) studied this question.

synapsesocial.com/papers/68dd89d7fe798ba2fc497ad1https://doi.org/10.52403/ijshr.20250321
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation Of Some Haematological Parameters, Liver Enzymes And Bilirubin In Sickle Cell Diseased Patients Attending Federal University Teaching Hospita, Owerri2024
  2. 2Hematological and biochemical alterations in school-aged children with sickling cell disorders indicate an elevated risk of liver and cardiovascular diseases2025
  3. 3Complete Blood Count Profile in Steady State Sickle Cell Disease Patient: A Systematic Review and Meta‐Analysis2026 · 1 citations
  4. 4Changes in Haematological and Clinical Parameters in Sickle Cell Disease Patients on Hydroxyurea: A Before and After Non-Experimental Retrospective Study2024 · 2 citations
  5. 5A cross-sectional study on BMI, anemia, and quality of life in children with sickle cell disease2025