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March 21, 2026Health Science ReportsOpen Access

Complete Blood Count Profile in Steady State Sickle Cell Disease Patient: A Systematic Review and Meta‐Analysis

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Authors

JSJosué Louokdom SimoUniversité des MontagnesRTRomaric De Manfouo TuonoIYI. YongUniversité de Yaoundé I

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Implication

Systematic review and meta-analysis reveal hematological profiles in sickle cell disease patients, suggesting a need for specific reference values.

Key Points

  • The research aims to synthesize data on the complete blood count profiles in sickle cell disease patients during steady state periods.
  • Conducted a systematic review and meta-analysis of studies from 2000 to 2025.
  • Included 21 descriptive cross-sectional studies.
  • Data were analyzed using R version 4.3.2 with a random effects model.
  • Employed the JBI Critical Appraisal Checklist for bias assessment.
  • Mean red blood cell count was 3.42 T/L with a range from 2.54 to 11.40 T/L.
  • Mean hemoglobin was 8.83 g/dL, ranging from 7.51 to 11.62 g/dL.
  • Mean leukocyte count was 10.87 G/L, with values ranging from 7.10 to 15.64 G/L.
  • Mean platelet count was 332.07 G/L, ranging from 121.44 to 450.00 G/L.

Cite This Study

Simo et al. (2026) studied this question.

synapsesocial.com/papers/69be38da6e48c4981c67998fhttps://doi.org/10.1002/hsr2.72143
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