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Meta-analysis compares hematological profiles during vaso-occlusive crises and steady-state in sickle cell disease, indicating the need for tailored reference values.
This meta-analysis confirms the substantial influence of VOEs on red blood cell, white blood cell, and platelet parameters, as well as their associated indices. Importantly, although hematological parameters in the steady state are less severely altered than during VOEs, they often remain outside conventional reference ranges, reflecting a distinct physiological baseline in SCD patients. These findings underscore the urgent need for prospective studies to define specific hematological reference values for steady-state SCD patients, which is essential for optimizing their clinical management.
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Tuono et al. (2026) studied this question.
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