Case report of a 21-year-old woman with hyperreflexia and cranial nerve involvement in pregnancy, suggesting diagnostic challenges for Guillain-Barre syndrome.
Guillain–Barre syndrome (GBS) is a common cause of acute peripheral neuropathy and is characterized by hyporeflexia or areflexia. Hyperreflexia has been rarely reported with acute motor axonal neuropathy. 21-year-old pregnant women presented with asymmetrical weakness of upper and lower limbs and change of voice. Weakness progressed in the hospital with involvement of multiple cranial nerves, preserved deep tendon jerks with extensor plantar and normal abdominal reflexes atypical variants with preserved or brisk reflexes, asymmetrical weakness, bulbar involvement are rare and diagnostically challenging, particularly in pregnancy. She was treated with IV immunoglobulin and IV methylprednisolone. She able to walk with support with normal voice at the time of discharge. GBS should be a differential diagnosis in patients with acute quadriparesis even if there are preserved deep tendon reflexes.
No takes yet. Share an insight, caveat, or question.
Teja et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: