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October 1, 2025NutrientsOpen Access

Sweet Taste Adaptation to Sugars, Sucralose, and Their Blends: A Human and Rodent Perspective

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Authors

SOStephanie I. OkoyeUniversity of Illinois Urbana-ChampaignMKMinjae KimTufts UniversitySPS. J. PettyUniversity of Illinois Urbana-Champaign

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Implication

Experimental analysis reveals that sweetener composition influences sweet taste perception and adaptation in both human and rodent models.

Key Points

  • Habitual low-calorie sweetener use does not affect sweetness perception or adaptation in humans.
  • Sucralose alone shows greater adaptation compared to blends with sugars in both human and rodent studies.
  • Both glucose and fructose demonstrate adaptation, but less than sucralose, with significant declines in sweetness perception over trials.
  • Sweetener composition impacts sweet taste adaptation mechanisms, guiding the development of low-calorie sweetener products.

Cite This Study

Okoye et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497ce0https://doi.org/10.3390/nu17193075
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sensory profiling of natural sweeteners and sucrose–sweetener binary mixtures2023 · 12 citations
  2. 2NoRMCorre: An online algorithm for piecewise rigid motion correction of calcium imaging data2017 · 1,179 citations
  3. 3Current Advances and Future Aspects of Sweetener Synergy: Properties, Evaluation Methods and Molecular Mechanisms2022 · 18 citations