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October 1, 2025

Efficacy of Combination and Single Therapy in Bell's Palsy: A Systematic Review and Meta-Analysis.

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Authors

NDNima DehghaniMAMohadeseh AzarsinaXMXaniar Mahmoudi

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Overview

Systematic review shows combination therapy improves facial paralysis outcomes compared to single treatment, indicating a potential shift in treatment strategies.

Key Points

  • Combination therapy significantly enhances effectiveness compared to single corticosteroid therapy in bell's palsy.
  • Among antiviral agents, famciclovir, valacyclovir, and acyclovir showed the highest efficacy when used with corticosteroids.
  • A systematic review and meta-analysis evaluated 14 studies using statistical analysis to support findings on treatment effectiveness.
  • No significant bias was detected, reinforcing the reliability of the results in informing treatment approaches for facial paralysis.

Cite This Study

Dehghani et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497e8ehttps://doi.org/10.61186/wjps.14.2.3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Corticosteroids vs. Combined Corticosteroid/Antiviral Therapy in Bell's Palsy Treatment: A Randomized Controlled Trial2025
  2. 2Comparative Analysis of Treatment Modalities for Bell's Palsy and Their Effectiveness2025
  3. 3Corticosteroids and antiviral treatment for Bell's palsy (idiopathic facial paralysis)2026
  4. 4A meta-analysis and modelling of the duration of symptoms in Bell’s palsy in the Scottish and Scandinavian trials2025
  5. 5Statistical Fragility of Steroid‐Antiviral Therapy for Bell's Palsy: A Systematic Review of Randomized Controlled Trials2025 · 1 citations