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October 1, 2025

Recent advances in azide-free 1,2,3-triazole construction from diverse nitrogen sources.

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Authors

XZXinpeng ZhouCLChangchun Liu

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Overview

This review summarizes novel azide-free methods for synthesizing 1,2,3-triazoles using various nitrogen sources, emphasizing efficiency and safety.

Key Points

  • Azide-free methods enable the synthesis of diverse 1,2,3-triazoles with improved safety and functional group tolerance.
  • New approaches utilize nitrogen sources like hydrazones and diazo compounds, showcasing the flexibility of synthetic pathways.
  • The review covers techniques from 2017 to 2025, analyzing reaction mechanisms and efficiency metrics for safer alternatives.
  • Future research targets non-precious metal catalysis and computational methods to streamline the synthesis of functionalized triazole derivatives.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497e9chttps://doi.org/10.1039/d5ob01050k
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