Divergent Regioselective Synthesis of Functionalized 1,2,3‐1H‐Triazoles from Nitriles and Arylazides under Metal‐ and/or Solvent‐free Conditions

Highly selective and divergent syntheses, which are crucial in both organic synthesis and medicinal chemistry, involve significant advancements in compound accessibility. By modifying α‐cyano esters into α‐cyano ketones, the synthesis pathway broadens to include a diverse range of 4‐CN, 5‐amino, and 5‐arylamino derivatives of 1,2,3‐triazoles, which are achieved notably through the Dimroth rearrangement. This versatility extends further with the potential for a triple cascade reaction, leading to the production of carboximidamide compounds, which are facilitated by the Cornforth rearrangement. Advancements in compound accessibility not only expand the repertoire of synthesized molecules but also open new avenues for potential pharmacological agents. Building on these findings, we have developed an innovative and efficient method for the divergent synthesis of functionalized 1,2,3‐triazoles. This method strategically utilizes α‐cyanocarbonyls and arylazides by harnessing their reactivity and compatibility to orchestrate a variety of molecular transformations. By optimizing these substrates, our goal is to simplify synthetic routes, improve product yields, and accelerate the discovery and development of new chemical entities with promising biological activities.