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Effect of Seasonal Influenza Vaccines on Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Ferrets

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Vaccination reduces H5N1 infection risk in ferrets, suggesting cross-reactive immunity from influenza vaccines.

Immunization with seasonal influenza vaccines provides partial protection against H5N1 infection in ferrets.
Ferrets showed a response characterized by cross-reactive antibodies targeting H5N1 virus antigens.
Previous H1N1 infection was known to confer protection, but the effectiveness of seasonal vaccines was uncertain.
These findings highlight the potential for seasonal vaccines in mitigating avian influenza risks.

Sun et al. (2025) studied this question.

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