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October 1, 2025European Heart Journal - Imaging Methods and PracticeOpen Access

Functional and Morphological Determinants of Left Ventricular Fibrosis in Patients with Mitral Annular Disjunction in Cardiac Magnetic Resonance Imaging

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Authors

MRMartin F. ReinerDEDaniel Escribano-GarcíaFGFederica Guidetti

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Overview

Retrospective cohort study reveals age and LV segment motion influence fibrosis in MAD patients, suggesting implications for monitoring.

Key Points

  • Age and accelerated longitudinal motion were identified as independent determinants of fibrosis in the inferolateral LV wall.
  • Multivariable analysis indicated that accelerated motion had a strong association with replacement fibrosis, with an odds ratio of 11.10.
  • Mitral valve prolapse and mitral annular disjunction size significantly correlated with increased motion in patients with fibrosis.
  • The study emphasizes the importance of cardiac magnetic resonance imaging in assessing structural heart changes associated with MAD.

Cite This Study

Reiner et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc4984f5https://doi.org/10.1093/ehjimp/qyaf120
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional and morphological predictors of left ventricular fibrosis in patients with mitral annular disjunction in cardiac magnetic resonance imaging2025 · 1 citations
  2. 2Predictors of Left Ventricular Fibrosis in Mitral Annular Disjunction: Cardiac Magnetic Resonance Imaging Study2026
  3. 3Localised hypertrophy of the basal inferolateral wall of the left ventricle is common in women with Marfan syndrome and mitral valve prolapse and is associated with prognosis2025
  4. 4Left Ventricular Fibrosis by Cardiac Magnetic Resonance Tissue Characterization in Chronic Mitral Regurgitation Patients2024 · 2 citations
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