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October 1, 2025Journal of Indian Academy of Oral Medicine and RadiologyOpen Access

Phytochemical Profiling and Cytotoxic Potential of Musa acuminata Stem Extracts against Transformed Dysplastic Oral Keratinocytes (T-DOK): An In vitro Chemoprevention Study

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Authors

ERE. Gracelin RanjithaNRN. RakeshADAngeline Deepthi

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Overview

Cytotoxicity analysis reveals Musa acuminata extracts significantly affect transformed dysplastic oral keratinocytes, suggesting potential for chemoprevention.

Key Points

  • Musa acuminata extracts demonstrated significant cytotoxicity against T-DOK cell lines after 24, 48, and 72 hours of treatment.
  • Phytochemical profiling revealed 0.078 mg/mL of phenolic compounds and 0.042 mg/mL of flavonoids in the extracts.
  • Cytotoxic effects were quantified with IC50 values of 223.08 µg/mL, 181.35 µg/mL, and 163.825 µg/mL across various time points.
  • This study supports the potential of Musa acuminata as a source for chemopreventive agents in oral cancer.

Cite This Study

Ranjitha et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc498656https://doi.org/10.4103/jiaomr.jiaomr_188_25
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