Lithium intoxication presents severe symptoms in patients with bipolar disorders, highlighting the need for effective management strategies.
Lithium carbonate is utilized to manage bipolar disorders as a mood-stabilizing medication, while the intoxication causes tremor, ataxia, confusion, hyperreflexia, myoclonus, dysarthria, and seizures, besides cardiovascular, gastrointestinal, renal and endocrinological symptoms; the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) means persistent symptoms after the stop of this drug use, with manifestations of brainstem and cerebellar dysfunctions, extrapyramidal disorders, dementia, and some atypical presentations (Bystrzyński et al., 2025)
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Santos et al. (2025) studied this question.
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