Chemical Composition of Plectranthus amboinicus Leaf Essential Oil from Phetchabun, Thailand, and Its Potential to Combat Enteropathogenic Bacteria and Regulate Blood Pressure

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Observational analysis showed strong bactericidal activity against pathogenic bacteria, indicating potential for hypertension treatment.

PAEO demonstrated moderate to strong bactericidal activity against Escherichia coli and others, with MIC values from 1 to 2 mg/mL.
The essential oil's dominant compounds included shyobunol (9.1%) and germacrene D (8.3%), as identified by GC-MS analysis.
Inhibition of angiotensin-converting enzyme 1 exceeded 70% at 1 mg/mL, suggesting its role in hypertension management.
Further clinical investigation is warranted given PAEO's multifunctional potential in treating microbial infections and regulating blood pressure.

Sutinan et al. (2025) studied this question.

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