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This is a Quantitative Study study.

October 1, 2025Open Access

Quantifying the number of people who would benefit from HIV pre-exposure prophylaxis (PrEP) in the United States: a comparison of behavioral, acquisition-risk based, and economic metrics

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Metrics reveal that 31-57% of men who have sex with men may benefit from HIV PrEP, suggesting a need for targeted programs.

An estimated 31-57% of MSM could benefit from PrEP based on HIV acquisition risk thresholds.
For people who inject drugs, estimates of benefit range from 7% using cost-per-QALY to 60% at the highest risk threshold.
Men who have sex with women and women who have sex with men showed the lowest benefit estimates at 0-11%, yet their population size remains significant.
These estimates highlight the need for a broader framework to assess PrEP requirements at both population and program levels.

Rönn et al. (2025) studied this question.

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