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October 1, 2025Tropical Journal of Natural Product ResearchOpen Access

Phaleria Macrocarpa Extract Reduced Endometriosis Lesions by Regulating Inflammatory Protein and Inhibiting Ki67 and Vegf-A Protein

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Authors

MMMaharani MaharaniSSSutrisno SutrisnoSWSri Winarsih

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Overview

Animal study shows that Phaleria macrocarpa extract reduces endometriosis lesions in mice, indicating potential therapeutic benefits.

Key Points

  • Phaleria macrocarpa extract significantly reduced endometriosis lesions by modulating inflammation and protein expression levels.
  • The study revealed that PM extract decreased COX-2 levels in a dose-dependent manner across multiple treatment groups.
  • Using immunohistochemistry and ELISA, the study assessed levels of inflammatory proteins, demonstrating effective regulation by PM extract.
  • These findings suggest that Phaleria macrocarpa may provide a novel approach for managing endometriosis by targeting inflammatory pathways.

Cite This Study

Maharani et al. (2025) studied this question.

synapsesocial.com/papers/68dd91cbfe798ba2fc4988efhttps://doi.org/10.26538/tjnpr/v9i9.20
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice2026
  2. 2The Impact of Phaleria macrocarpa Fruit Flavonoid Extract on Endometrial Thickness in Mice Menopausal Model2024
  3. 3Effects of chronic particulate matter exposure on endometriosis-associated signaling pathways and disease progression2025 · 5 citations
  4. 4Targeting E-Selectin and ICAM1 Suppresses Endometriosis Progression by Disrupting the Inflammation–Fibrosis Axis and Reducing Local M2 Macrophage Infiltration2026
  5. 5The Efficacy of Polyphenolic Compounds in the Treatment of Endometriosis: A Preclinical Systematic Review and Meta-Analysis2026