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October 1, 2025AJP Heart and Circulatory Physiology

Mechanisms of exercise limitation in heart failure with preserved ejection fraction and obesity: A case of engine-chassis mismatch

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Authors

SFStephen FoulkesCardio-OncologySFSara FerreiraPolytechnic Institute of Castelo BrancoMMMaurício MilaniGeneral / Preventive / Lipids

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Overview

Case-control study evaluates peak oxygen uptake and cardiac output in obesity and heart failure populations, suggesting a need for comprehensive management strategies.

Key Points

  • HFpEF obese patients show preserved absolute peak oxygen uptake despite lower bodyweight-indexed activity levels.
  • Statistically significant differences were observed in peak exercise cardiac output and stroke volume among HFpEF subgroups.
  • Cardiopulmonary exercise testing highlighted impaired VO 2 peak and central factors in HFpEF patients compared to controls.
  • Incorporating weight loss and comprehensive therapies is essential to tackle exercise intolerance in HFpEF patients.

Cite This Study

Foulkes et al. (2025) studied this question.

synapsesocial.com/papers/68dd91cffe798ba2fc498c99https://doi.org/10.1152/ajpheart.00587.2025
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