Exercise Tolerance can Explain the Obesity Paradox in Patients with Systolic Heart Failure: Data from the MECKI Score Research Group
Population
4,623 patients with systolic heart failure recruited from 24 Italian HF centres
Design
Cohort
Follow-up
median 1113 (553-1803) days
Authors
Discussion
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Member takes
Implication
BMI should not guide HF prognosis without fitness data; leaves open whether cardiorespiratory fitness mediates the obesity paradox.
Structured PICO
P
Population
4,623 patients with systolic heart failure (LVEF 31.5 ± 9.5%, BMI 26.2 ± 3.6 kg/m2) recruited from 24 Italian HF centres
O
Outcome
All-cause and cardiovascular deaths including urgent cardiac transplanthard clinical
Cardiorespiratory fitness explains the obesity paradox in systolic heart failure, as the apparent survival benefit of higher BMI disappears when adjusting for exercise tolerance.
Cite This Study
Piepoli et al. (2016) studied this question.