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Evaluation of Potential Molecular Targets of the Alkaloid Epiisopiloturine, Involved in Cardioprotective Effects, Using Computational Molecular Docking in an Animal Model of Cardiac Ischemia and Reperfusion

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Animal model reveals that epiisopiloturine reduces ventricular arrhythmias and cardiac injury, indicating its cardioprotective potential.

Administration of epiisopiloturine before cardiac ischemia significantly reduces ventricular arrhythmias and lethality.
EPI15 + CIR treatment resulted in a decrease in atrioventricular block incidence from 85.7% to 21.4%.
Both doses of epiisopiloturine lowered serum creatine kinase-MB compared to control, indicating reduced cardiac injury.
These findings suggest that the antioxidant effects of epiisopiloturine may offer new treatment options for acute myocardial infarction.

Rodrigues et al. (2025) studied this question.

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