January 1, 2017Journal of Molecular Imaging & Dynamics

A Simple and Efficient Methodology for the Study of Cardioprotective Drugs in Animal Model of Cardiac Ischemia-Reperfusion

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Why the study?

Does nifedipine reduce ventricular arrhythmias, atrio-ventricular blockade, and lethality in an adult male Wistar rat model of cardiac ischemia-reperfusion?

Population

Adult male Wistar rats anesthetized and kept under mechanical ventilation, submitted to cardiac…

Comparison

Nifedipine 30 mg/kg intravenously administered… vs Untreated cardiac I/R group and SHAM-operated…

Design

Preclinical

Authors

JTJosé Gustavo Padrão TavaresUniversidade do Porto ÊVÊnio R. VasquesUniversidade Federal do ABC MRMaria do Carmo Maia Reis

Discussion

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Implication

Nifedipine pretreatment may protect rat ischemia-reperfusion models; hypothesis-generating and requires human trials before any clinical consideration.

Structured PICO

Does nifedipine reduce ventricular arrhythmias, atrio-ventricular blockade, and lethality in an adult male Wistar rat model of cardiac ischemia-reperfusion?

Population

Adult male Wistar rats (14 - 16-week-old) anesthetized and kept under mechanical ventilation, submitted to cardiac ischemia-reperfusion (I/R) via mechanical occlusion of the left anterior descendent coronary artery for 10 min followed by reperfusion.

Intervention

Nifedipine 30 mg/kg intravenously (IV) administered before ischemia.

Comparator

Untreated cardiac I/R group and SHAM-operated group (surgical procedures without coronary occlusion).

Outcome

Incidence of ventricular arrhythmia (VA), atrio-ventricular blockade (AVB), and lethality (LET).surrogate

A simple and efficient rat model of cardiac ischemia-reperfusion successfully demonstrates the cardioprotective effects of nifedipine on electrical activity and lethality.

Cite This Study

Tavares et al. (2017) studied this question.

synapsesocial.com/papers/6a8a8ba1b4e829b19bd48bfa https://doi.org/10.4172/2155-9937.1000133

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Implication

Nifedipine pretreatment may protect rat ischemia-reperfusion models; hypothesis-generating and requires human trials before any clinical consideration.

A Simple and Efficient Methodology for the Study of Cardioprotective Drugs in Animal Model of Cardiac Ischemia-Reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Simple and Efficient Methodology for the Study of Cardioprotective Drugs in Animal Model of Cardiac Ischemia-Reperfusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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