Key result
A semi-minimally invasive method to induce myocardial infarction in rats, combined with an ex vivo working heart system, provides a reproducible model for evaluating cardiac function and treatments.
Why the study?
An easily and highly reproducible myocardial infarction induction procedure is needed to investigate pathological changes and evaluate novel treatments for acute MI, remodeling, and heart failure.
Population
Rats
Design
Methodological and procedural protocol
Authors
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Enables standardized preclinical MI models for testing therapies; leaves open translation to clinical practice without further validation.
Pilz et al. (2020) studied Myocardial infarction. Semi-minimal invasive method to induce myocardial infarction was evaluated. A semi-minimally invasive method to induce myocardial infarction in rats, combined with an ex vivo working heart system, provides a reproducible model for evaluating cardiac function and treatments.
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