Observational analysis found levofloxacin induces MexB-OprM efflux pump expression in Pseudomonas aeruginosa isolates, indicating a link to antibiotic resistance.
Key Points
Levofloxacin significantly upregulates the MexB-OprM efflux pump genes in Pseudomonas aeruginosa.
About 25% of blood specimens tested positive for Pseudomonas aeruginosa, showing 100% resistance to several antibiotics.
Molecular tests revealed that all isolates carried the OprM gene, with a significant proportion also carrying the MexB gene.
The upregulation of MexB correlates with increased levofloxacin minimal inhibitory concentration values, underscoring resistance mechanisms.