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October 1, 2025Journal of Pain ResearchOpen Access

Bridging Pain and Motoric Cognitive Risk Syndrome: Mediating Effect of Handgrip Strength

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Authors

XZXiaojiang ZhaoYZYingcheng ZhuLHLiang Han

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Overview

Cross-sectional study finds pain increases likelihood of motoric cognitive risk syndrome, while handgrip strength indicates protective benefits.

Key Points

  • Pain significantly increases the likelihood of developing motoric cognitive risk syndrome (MCR).
  • Handgrip strength (HGS) is negatively associated with MCR prevalence, reducing likelihood with increases in strength.
  • Mediation analysis shows that HGS explains a substantial portion of the relationship between chronic pain and MCR.
  • Demographic stratification provides insights into how pain and HGS impact MCR in different populations.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc499706https://doi.org/10.2147/jpr.s535444
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