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Esculetin Attenuates Doxorubicin‐Induced Cardiotoxicity via Modulation of Apoptotic and Mitochondrial Gene Expression Networks

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Esculetin significantly mitigates doxorubicin-induced cardiotoxicity and indicates potential for cardioprotection in patients.
Doxorubicin treatment raised cardiac injury markers like CK-MB and cTn-I, implicating damaged heart tissue.
Evaluation involved random assignment of male Wistar rats to treatment groups and assessments of gene expression via RT-qPCR.
Findings suggest the importance of further validation at the protein level to fully understand esculetin’s cardioprotective mechanisms.

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Animal study shows esculetin's cardioprotective effects against doxorubicin, highlighting apoptosis and mitochondrial involvement.

Demir et al. (2025) studied this question.

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