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October 1, 2025Natural Product Research0 citations

Isolation and Evaluation of Ellagic Acid C and Aspergone R from Diaporthe sp.

Ellagic acid C and aspergone R, two undescribed pyrones from the endophytic fungus Diaporthe sp. CB10100: biological evaluation, molecular docking and molecular dynamics studies

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Authors

YXYinhong XiangHYHao YangYZYa-Ni Zhong

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Overview

Isolation reveals ellagic acid C and aspergone R from endophytic fungus, suggesting anti-inflammatory potential.

Key Points

  • Ellagic acid C and aspergone R showed reduced expression of iNOS and COX-2 in response to LPS stimulation.
  • Molecular docking suggested that both compounds could interact with key active sites of iNOS and COX-2 proteins.
  • Molecular dynamics simulations indicated that aspergone R displays greater binding stability with COX-2 than other compounds.
  • Both compounds exhibited antimicrobial activity against MRSA, Klebsiella pneumoniae, and Mycolicibacterium smegmatis.

Cite This Study

Xiang et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc4998a7https://doi.org/10.1080/14786419.2025.2565814
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