Reveals the antimicrobial and acetylcholinesterase inhibitory activities of compounds from Aspergillus foetidus, suggesting further bioactive potential.
A new naphtho‐γ‐pyrone dimer, asperforone A ( 1 ), along with thirteen known compounds, was isolated from the endophytic fungus Aspergillus foetidus of Gardenia jasminoides J. Ellis. Their structures were elucidated through comprehensive spectroscopic analysis and by comparison with literature data. Aspernigrin A ( 11 ) showed notable acetylcholinesterase inhibitory activity (46.98% at 50 µM), while asperforone A ( 1 ) and asperpyrone D ( 9 ) exhibited antimicrobial activity against Plectosphaerella cucumerina (minimum inhibitory concentration = 32 µg/mL). This study extends the chemical profile of A. foetidus and underscores its potential for bioactive metabolite discovery.
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Wang et al. (2026) studied this question.
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