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August 14, 2026Journal of Natural Products0 citations

Chimeric Pyridone Alkaloids Isolated from Mangrove Endophytic Fungus Aspergillus niger

Chimeric Pyridone Alkaloids from the Mangrove Endophytic Fungus Aspergillus niger

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Authors

XCXiao-Rao Chen YLYuying Lin DLDan-Xuan Li

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Overview

In vitro study uncovers novel chimeric pyridone alkaloids from Aspergillus niger with antibacterial and antitumor activities, highlighting their potential as therapeutic lead compounds.

Key Points

To isolate and structurally characterize novel chimeric pyridone alkaloids from the mangrove endophytic fungus Aspergillus niger H6a and evaluate their antimicrobial and antitumor activities.
Purified 34 alkaloids from Aspergillus niger H6a and elucidated their structures via HRESIMS, NMR, single-crystal X-ray diffraction, TDDFT-ECD calculations, and Marfey’s derivatization.
Assessed antibacterial efficacy against Enterococcus faecalis and Micrococcus luteus and tested antitumor mechanisms against HeLa cell lines.
Identified 28 new compounds (aspernigrins F1–F8, G1–G5, H1–H7, and I–P), including amphiphilic structures bearing 2-aminododecanoic acid and ester-linked neo-inositol groups.
Compound 26 exhibited antibacterial activity against E. faecalis (MIC 8.0 μg/mL) and M. luteus (MIC 16.0 μg/mL).
Compound 27 demonstrated antitumor activity against HeLa cells (IC50 = 15.9 μM), arresting the cell cycle at G0/G1 and inducing mitochondrial-mediated apoptosis.

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Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec754b70b84ec8b913a38 https://doi.org/10.1021/acs.jnatprod.6c00694

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August 14, 2026Journal of Natural Products0 citations

Chimeric Pyridone Alkaloids Isolated from Mangrove Endophytic Fungus Aspergillus niger

Chimeric Pyridone Alkaloids from the Mangrove Endophytic Fungus Aspergillus niger

View Full Paper

Authors

XCXiao-Rao Chen YLYuying Lin DLDan-Xuan Li

Discussion

Member takes

Overview

In vitro study uncovers novel chimeric pyridone alkaloids from Aspergillus niger with antibacterial and antitumor activities, highlighting their potential as therapeutic lead compounds.

Key Points

To isolate and structurally characterize novel chimeric pyridone alkaloids from the mangrove endophytic fungus Aspergillus niger H6a and evaluate their antimicrobial and antitumor activities.
Purified 34 alkaloids from Aspergillus niger H6a and elucidated their structures via HRESIMS, NMR, single-crystal X-ray diffraction, TDDFT-ECD calculations, and Marfey’s derivatization.
Assessed antibacterial efficacy against Enterococcus faecalis and Micrococcus luteus and tested antitumor mechanisms against HeLa cell lines.
Identified 28 new compounds (aspernigrins F1–F8, G1–G5, H1–H7, and I–P), including amphiphilic structures bearing 2-aminododecanoic acid and ester-linked neo-inositol groups.
Compound 26 exhibited antibacterial activity against E. faecalis (MIC 8.0 μg/mL) and M. luteus (MIC 16.0 μg/mL).
Compound 27 demonstrated antitumor activity against HeLa cells (IC50 = 15.9 μM), arresting the cell cycle at G0/G1 and inducing mitochondrial-mediated apoptosis.

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View Full Paper

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec754b70b84ec8b913a38 https://doi.org/10.1021/acs.jnatprod.6c00694

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