Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2026The Natural Products Journal

Cytotoxic Alkaloids Isolated from the Mangrove Endophytic FungusAspergillus fumigatus BF18

View Full Paper
Ask AI
Bookmark
Share

Authors

XHXin HuangBDBo DingYWYi-Xiang Wang

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates cytotoxic activity of alkaloids from Aspergillus fumigatus BF-18, suggesting therapeutic potential.

Key Points

  • To isolate and identify cytotoxic secondary metabolites from Aspergillus fumigatus BF-18 and evaluate their effects against cancer cell lines.
  • Isolated alkaloids from Aspergillus fumigatus BF-18 fermented in rice solid medium and extracted with MeOH.
  • Purified extracts were analyzed using silica gel column chromatography and semi-preparative HPLC.
  • Cytotoxicity was assessed using the MTT assay against H1299 lung cancer cell lines.
  • Nine alkaloid compounds were identified, including chaetominine B, a new indole-quinoline alkaloid.
  • Pseurotin G significantly inhibited H1299 cell proliferation with an IC50 of 1.1 μM.
  • Chaetominine exhibited weak anti-proliferative activity against H1299 and A549 cells, indicating selective antitumor properties.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a3631cedb0793dc1a53891bhttps://doi.org/10.2174/0122103155440248260203083036
View Full Paper
Ask AI
Bookmark
Share