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April 2, 2024ChemistrySelect

In Vitro and In Silico Anticancer Evaluation of Secondary Metabolites from an Endophytic Fungus Aspergillus Fumigatus Isolated from Monarda Citriodora

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Authors

NGNidhi GuptaGSGurpreet SinghAQArem Qayum

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Overview

In vitro study reveals selective cytotoxicity of Aspergillus fumigatus metabolites in human colon cancer cells, highlighting therapeutic potential.

Key Points

  • Secondary metabolites from endophytic Aspergillus fumigatus demonstrate selective cytotoxicity against colon cancer cells while remaining nontoxic to normal human cells.
  • An IC50 value below 1.0 μM made gliotoxin the most potent agent against cancer lines, but the compound showed substantial cytotoxicity toward normal human cells.
  • Docking studies using Gaussian 09 demonstrated preferential binding affinity for TRAF2 protein, aligning with secondary metabolites screening in tumor cell assays.
  • Highlights potential for antibiotic FD838 and monomethylsulochrin as colon cancer therapeutics—in vitro cell model; further preclinical in vivo validation needed.

Cite This Study

Gupta et al. (2024) studied this question.

synapsesocial.com/papers/68e70b3ab6db643587684b33https://doi.org/10.1002/slct.202400637
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Also Consider

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