Ameliorative Effects of Kiwifruit and Star Anise on the Negative Effects Induced by Ehrlich Ascites Carcinoma on Bone Marrow

Kiwi fruit (Actinidia deliciosa) and star anise (Illicium verum) are the richest sources of minerals and vitamins. Fractionation of phenolic compounds by HPLC for kiwi fruit showed that the main compounds in the methanol extract were syringic acid, chrysin, and quercetin. Star anise had the highest concentrations of syringic acid, quercetin, and gallic acid, respectively. Mice in biological experiments were divided into six groups. Group I was the negative control, while Group II was the positive control, and they were both injected with EAC. Group III was injected with EAC and the chemical drug cisplatin. Groups IV, V, and VI mice were injected with EAC separately and treated with kiwifruit juice, star anise, and a mixture of kiwifruit juice and star anise. The results showed that cell viability was best in kiwi fruit, followed by the mixture and star anise. In contrast, the treatment with cisplatin as chemotherapy for EAC resulted in lower cell viability compared to the different juices. Mice in Groups IV, V, and VI, as well as those treated with cisplatin, were observed to have an increased expansion of myeloid cells (CD11b+LY6G+). The results from flow cytometry indicated enhanced levels of CD69 and CD62L, in addition to CD4+ and CD8+ T cells in the various experimental mice groups. It can be concluded that kiwi fruit and star anise have high nutritional value and the highest concentrations of phenolic compounds. These characteristics contribute to a high activity of natural antioxidants and medicinal properties.