This approach utilizes triplet nitrene to facilitate selective azidation of tertiary C–H bonds in dipeptides, indicating its potential in synthetic chemistry.
A photocatalytic C(sp³)–H azidation involving a triplet nitrene as a hydrogen atom abstractor is described. The key nitrene intermediate is generated through energy transfer to a sulfonyl azide, which also functions as an azide source. This method exhibits excellent selectivity for tertiary C–H bonds and is applicable to leucine-containing dipeptides.
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Shimamoto et al. (2025) studied this question.
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