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October 2, 2025Open Access

Serum cytokines during acute respiratory infection and relationship to age

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Authors

AGAmod GuptaHMHolden T. Maecker

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Overview

Analyzing cytokine variations in influenza infection across age ranges, highlighting age-related immune responses.

Key Points

  • Pro-inflammatory cytokines were significantly elevated in infected individuals, particularly in younger cohorts.
  • Cytokine responses were assessed using data from 181 healthy and 27 symptomatic individuals, focusing on infection status and age.
  • Ordinary least squares regression demonstrated the interaction of infection and age significantly affects cytokine behavior.
  • The study highlights inflammaging phenomena, revealing novel cytokine behaviors across diverse age groups in influenza infection.

Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/68de5da783cbc991d0a20c62https://doi.org/10.1101/2025.09.29.679372
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