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February 5, 2026International Journal of Molecular SciencesOpen Access

Cytokine Dynamics in Severe COVID-19 vs. Influenza A Elderly Patients: A Prospective Comparative Study

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Authors

MRMihai Aronel RusIuliu Hațieganu University of Medicine and PharmacyAHAdina HuțanuUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu MureșDLDaniel Corneliu LeucuțaIuliu Hațieganu University of Medicine and Pharmacy

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Implication

Prospective cohort study analyzes cytokine levels in elderly COVID-19 and FluA patients, indicating ICU outcomes.

Key Points

  • This research aims to compare cytokine dynamics and their prognostic significance in elderly patients with COVID-19 versus influenza A.
  • Conducted a prospective cohort study of hospitalized adults aged 60 or older with COVID-19 or FluA.
  • Measured serum levels of specific cytokines on Day 1 and Day 5 using Luminex® technology.
  • Analyzed associations between cytokine levels and non-invasive ventilation using ROC analysis and logistic regression.
  • COVID-19 patients had significantly higher levels of IL-6, IL-10, and CXCL10 on Day 1 compared to FluA patients.
  • By Day 5, cytokine levels decreased in both groups and values converged.
  • Baseline IL-6 was identified as an independent predictor of non-invasive ventilation, while higher MCP-1 levels were linked to a reduced need for NIV.

Cite This Study

Rus et al. (2026) studied this question.

synapsesocial.com/papers/698434a6f1d9ada3c1fb30cbhttps://doi.org/10.3390/ijms27031463
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