What type of study is this?

October 2, 2025JBMR PlusOpen Access

Therapeutic potential of FGF19 in combatting osteosarcopenia: effects on muscle strength and bone health in aged male mice

View Full Paper

Ask AI

Bookmark

Authors

Observational analysis reports increased muscle strength and bone health in aged male mice receiving FGF19, suggesting a potential therapeutic role.

Treatment with FGF19 significantly increased muscle strength in aged male mice.
Daily injections for 21 days led to larger muscle fibers and improvements in muscle function, without increasing muscle mass.
X-ray microtomography revealed site-specific effects on bone, including increased cross-sectional area and changes in cortical porosity.
Histomorphometry showed only minor changes in bone cellular activities and gene expression after treatment, indicating relative stability.

Zhang et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Observational analysis reports increased muscle strength and bone health in aged male mice receiving FGF19, suggesting a potential therapeutic role.