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September 10, 2025

Fibroblast Growth Factor 19 Disrupts Cartilage Development Via the FGFR4/β-catenin Axis.

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Ex vivo models reveal FGF19 reduces chondrocyte maturation and cartilage growth via FGFR4, suggesting pathways for metabolic disorders.

FGF19 inhibits cartilage development through FGFR4 and β-catenin, impacting growth plate formation.
Maturation of chondrocytes is impaired by FGF19, which decreases growth plate thickness during adolescence.
The study utilizes an AAV-FGF19 overexpression model to assess its effects on cartilage differentiation.
Findings underscore the role of FGF19 in chondrogenesis, highlighting potential implications for metabolic skeletal disorders.

Chen et al. (2025) studied this question.

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