What question did this study set out to answer?

Investigate the role of FGF18 in promoting chondrocyte proliferation and its relationship with FOXN2 in post-traumatic osteoarthritis.

Fibroblast growth factor 18 stimulates chondrocyte proliferation by modulating FOXN2 to mitigate post-traumatic osteoarthritis in a mouse model

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Functional studies demonstrate that FGF18 promotes aggrecan synthesis in osteoarthritis, indicating a potential therapeutic mechanism.

Investigate the role of FGF18 in promoting chondrocyte proliferation and its relationship with FOXN2 in post-traumatic osteoarthritis.
Assessed FGF18 expression in articular cartilage of PTOA and normal controls.
Conducted functional studies on FGF18 overexpression effects on chondrocytes.
Performed intra-articular delivery of FGF18 in DMM-induced PTOA mouse models.
FGF18 expression was downregulated in PTOA cartilage compared to normal.
FGF18 overexpression enhanced chondrocyte proliferation and increased aggrecan synthesis.
Intra-articular FGF18 delivery reduced cartilage erosion and improved matrix integrity in DMM mice.

Huang et al. (2025) studied this question.

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