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This is a In Vitro Study study.

December 8, 2025Frontiers in Bioengineering and BiotechnologyOpen Access

Synoviocyte–chondrocyte triculture model for early-stage PTOA: fibronectin fragment-induced catabolic effects in vitro and in vivo

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Authors

HCHongsik ChoUniversity of Tennessee Health Science Center ASAnuradha SubramanianUniversity of Alabama in Huntsville

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Implication

In vitro and in vivo analysis shows that fibronectin fragments activate macrophages, suggesting a key role in post-traumatic osteoarthritis progression.

Key Points

Activation of macrophages by fibronectin fragments leads to increased inflammatory mediators and catabolic signaling.
Gene expression of inflammatory mediators MMP3 and TNF-α increased in response to trauma-related fibronectin fragments.
Developed a triculture model to simulate early post-traumatic inflammation, demonstrating physiological relevance.
Findings highlight the potential of this model for future mechanistic studies and therapeutic screening in PTOA.

Cite This Study

Cho et al. (2025) studied this question.

synapsesocial.com/papers/693624a44fa91c937236c292 https://doi.org/10.3389/fbioe.2025.1683333

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Implication

In vitro and in vivo analysis shows that fibronectin fragments activate macrophages, suggesting a key role in post-traumatic osteoarthritis progression.

Synoviocyte–chondrocyte triculture model for early-stage PTOA: fibronectin fragment-induced catabolic effects in vitro and in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

Synoviocyte–chondrocyte triculture model for early-stage PTOA: fibronectin fragment-induced catabolic effects in vitro and in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

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