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This is a Systematic Review study.

October 2, 2025GenesOpen Access

Genetic and Molecular Insights into Transforming Growth Factor-Beta Signaling in Periodontitis: A Systematic Review

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TGF-β1 levels are elevated in diseased gingival tissue, indicating a link to periodontal inflammation and possible harm.
Fifteen studies were reviewed, revealing the consistent association of TGF-β1 with probing depth and attachment loss in periodontitis.
The systematic review conducted a quality appraisal using PRISMA guidelines, ensuring comprehensive data analysis.
Findings suggest that standardized, isoform-specific studies are vital for understanding TGF-β's diagnostic and therapeutic potential.

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Systematic review reveals TGF-β1's role as a biomarker in periodontitis, highlighting its immune modulation effects.

Pawłaszek et al. (2025) studied this question.

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