Endothelin: A Potential Universal Systemic Biomarker

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Endothelin-1 levels are found to be significantly higher in patients with hypertension and heart failure.
Increased ET-1 occurs in chronic kidney disease, liver failure, and autoimmune diseases, indicating broad relevance.
Statistical analysis revealed consistent patterns of elevated ET-1 across different pathological conditions.
The findings suggest ET-1 levels elevate with disease severity, highlighting its potential as a universal biomarker.

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This review evaluates plasma ET-1 levels in heart failure and hypertension, suggesting its utility as a biomarker.

Zacharioudaki et al. (2025) studied this question.

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