Key result
Plasma levels of ET-1 and ET-3 were altered differently across various conditions including chronic hemodialysis, acute myocardial infarction, surgery, and strenuous exercise.
Why the study?
Are plasma concentrations of endothelin-1 and endothelin-3 altered differently across various physiological and pathophysiological conditions?
Population
Patients on chronic hemodialysis, age-matched normal subjects, patients with acute myocardial infarction…
Design
Cross-sectional
Authors
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ET-1 and ET-3 show distinct alterations by condition; hypothesis-generating and should not yet change practice.
Observational
Are plasma concentrations of endothelin-1 and endothelin-3 altered differently across various physiological and pathophysiological conditions?
The distinct alteration patterns of ET-1 and ET-3 across various conditions suggest they play different physiological and pathophysiological roles in humans.
Miyauchi et al. (1991) conducted an observational in Various pathophysiological conditions (chronic hemodialysis, acute myocardial infarction, surgery). Various pathophysiological conditions and strenuous exercise vs. Age-matched normal subjects and healthy subjects before exercise was evaluated on Plasma concentrations of ET-1 and ET-3. Plasma levels of ET-1 and ET-3 were altered differently across various conditions including chronic hemodialysis, acute myocardial infarction, surgery, and strenuous exercise.
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