Key result
Plasma endothelin profiling revealed that Big-ET-1 is the predominant endothelin in sick dogs compared to healthy controls, suggesting distinct regulation of ET-1 and ET-3 in various diseases.
Why the study?
Do plasma concentrations and molecular profiles of endothelin-1 and -3 differ between healthy dogs and dogs with various diseases including congestive heart failure?
Population
Healthy dogs and dogs with congestive heart failure, renal failure, diabetes mellitus, and…
Comparison
Measurement of plasma endothelin-1 and -3… vs Healthy dogs
Design
Preclinical
Authors
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Big-ET-1 predominance may support biomarker exploration in canine disease; leaves open diagnostic utility in CHF pending validation studies.
Observational
Do plasma concentrations and molecular profiles of endothelin-1 and -3 differ between healthy dogs and dogs with various diseases including congestive heart failure?
Specific molecular forms of endothelin immunoreactivity, such as Big-ET-1, are predominant in dogs with various diseases including congestive heart failure, suggesting potential diagnostic importance.
Vollmar et al. (1995) conducted an observational in Congestive Heart Failure, Renal Failure, Diabetes Mellitus, and Hyperadrenocorticism. Plasma endothelin (ET)-1 and -3 measurement vs. Healthy dogs was evaluated on Plasma concentrations and immunoreactivity profiles of ET-1 and ET-3. Plasma endothelin profiling revealed that Big-ET-1 is the predominant endothelin in sick dogs compared to healthy controls, suggesting distinct regulation of ET-1 and ET-3 in various diseases.
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