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October 2, 2025Eurasian journal of applied biotechnologyOpen Access

Preclinical Development of a Chimeric Yellow Fever / Tick-Borne Encephalitis Virus as a Candidate Vaccine

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Authors

TKTolganay KulatayЕСЕ. С. СедоваASAlexandr Shevtsov

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Overview

Preclinical development demonstrates the potential of a chimeric virus for inducing immunity in murine models, suggesting easier vaccination strategies.

Key Points

  • The ChimeriVax YFV/TBEV virus showed robust replication in cell cultures, indicating effective vaccine development.
  • Immunization with the chimeric virus elicited potent neutralizing antibodies with a geometric mean titer of 4,076.
  • Murine models exhibited transient viremia without mortality, even at high doses, showcasing safety.
  • Cytokine production highlighted strong cellular immunity, marked by IFN-γ, TNF-α, and IL-2 responses upon stimulation.

Cite This Study

Kulatay et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a216cchttps://doi.org/10.11134/btp.3.2025.23
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Also Consider

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  1. 1Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening2025
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  3. 3Rational Design of a Chimpanzee Adenoviral-Vector Vaccine Against Yellow Fever Through the Modification of Antigen Transmembrane Domains2026
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  5. 5Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate2024 · 3 citations