Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 7, 2025Virologica SinicaOpen Access

Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening

View Full Paper
Ask AI
Bookmark
Share

Authors

TKTolganay KulatayЕСЕ. С. СедоваASAlexandr Shevtsov

Discussion

Loading...

Member takes

Overview

Prototype TBEV strain development highlights E51K variant's antiviral potential in Kazakhstan, suggesting vaccine avenues.

Key Points

  • The E51K variant of TBEV demonstrated non-lethal characteristics in mice, indicating an effective attenuation strategy.
  • A 100-fold titer increase was observed in the E51K variant during cell culture propagation, enhancing its replication abilities.
  • Using synthetic genomics, a reference TBEV strain was successfully generated to support vaccine development efforts in Kazakhstan.
  • Favipiravir showed antiviral effectiveness against TBEV, with inhibition observed in pharmacologically relevant concentrations.

Cite This Study

Kulatay et al. (2025) studied this question.

synapsesocial.com/papers/68e4ef18d9ba39bb23447af4https://doi.org/10.1016/j.virs.2025.09.010
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of an mRNA Vaccine for Tick-Borne Encephalitis: Selection of a Prototype Virus Strain2026
  2. 2Changes in the genome of tick-borne encephalitis virus during cultivation2024
  3. 3PRECLINICAL DEVELOPMENT OF A CHIMERIC YELLOW FEVER / TICK-BORNE ENCEPHALITIS VIRUS AS A CANDIDATE VACCINE2025
  4. 4Genetic Diversity of Tick-Borne Encephalitis Virus in Kyrgyzstan2025
  5. 5A replication-defective tick-borne encephalitis virus generated by NS1 trans-complementation confers robust protective efficacy2026