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October 1, 2025

Table 4 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy

Howard L. Li Soren Charmsaz Mari Nakazawa Stephanie Alden Madelena Brancati James M. Leatherman Ervin Griffin Hua‐Ling Tsai Nicole Groß Christopher J. Thoburn Alexei Hernandez Erin M. Coyne Sarah M. Shin Royce P. Lee Evan J. Lipson Burles A. Johnson Aliyah Pabani Yasser Ged Marina Baretti Julie R. Brahmer Jean Hoffman‐Censits Tanguy Y. Seiwert Daniel J. Zabransky Jennifer N. Durham Elizabeth M. Jaffee G. Scott Chandler Brittany L. Adler Won Jin Ho Chester Kao Mark Yarchoan

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Key Points

Specific immune-related adverse events (irAEs) correlate with fatigue in cancer patients receiving immune checkpoint inhibitors, highlighting a critical link.
Fatigue levels appear more pronounced in patients experiencing certain irAEs, suggesting that immune activation may play a role in this symptom.
Observational analysis examined fatigue patterns alongside immune activation signatures in cancer patients undergoing therapy.
Understanding these associations may help improve patient management and inform future treatment protocols.

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Implication

Observational analysis reveals specific irAEs linked to fatigue in cancer patients undergoing immune checkpoint inhibitor therapy.

Abstract

Specific irAEs experienced by patients with and without ICI-related fatigue.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a217ee https://doi.org/10.1158/2767-9764.30256011

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table 3 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025
2Table 2 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025
3Table 1 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025
4Figure 3 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025
5Figure 2 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025