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October 1, 2025

Table 3 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy

Howard L. Li Soren Charmsaz Mari Nakazawa Stephanie Alden Madelena Brancati James M. Leatherman Ervin Griffin Hua‐Ling Tsai Nicole Groß Christopher J. Thoburn Alexei Hernandez Erin M. Coyne Sarah M. Shin Royce P. Lee Evan J. Lipson Burles A. Johnson Aliyah Pabani Yasser Ged Marina Baretti Julie R. Brahmer Jean Hoffman‐Censits Tanguy Y. Seiwert Daniel J. Zabransky Jennifer N. Durham Elizabeth M. Jaffee G. Scott Chandler Brittany L. Adler Won Jin Ho Chester Kao Mark Yarchoan

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Key Points

Clinically significant irAEs were noted in patients experiencing immune activation signature related fatigue.
Patients with fatigue during ICI therapy exhibited distinct immune activation signatures, pointing to possible intervention areas.
Analysis utilized immune signatures to differentiate between fatigued and non-fatigued cancer patients undergoing ICI therapy.
Findings may indicate the need for tailored therapy approaches based on immune activation profiles associated with fatigue.

Implication

Observational study identifies immune activation signatures linked to fatigue in cancer patients, suggesting implications for ICI therapy management.

Abstract

Patients with and without ICI-related fatigue who developed clinically significant irAEs.

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2183c https://doi.org/10.1158/2767-9764.30256014

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table 4 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025
2Table 2 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025
3Table 1 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025
4Figure 3 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025
5Figure 2 from Immune Activation Signatures Associated with Fatigue in Cancer Patients Undergoing Immune Checkpoint Inhibitor Therapy2025